1.To review the systemic manifestations of cystic fibrosis (CF), with emphasis on findings seen in adolescents and young adults. 2.To emphasize the importance of radiologists in recognizing pertinent clinical presentations and imaging findings. 3.To recognize that genotypic and phenotypic presentation is variable, which may complicate diagnosis.

1.Pathophysiology and epidemiology of CF 2.Review of disease and related imaging findings in adolescent and adult patients using a body system approach and sample cases: -Head and neck sinus disease -Thorax: parenchymal, vascular and cardiac disease -Abdomen: pancreas, hepatobiliary, intestinal, nutritional disease -Genitourinary disease and infertility -Muskuloskeletal manifestations 3.Exampes of phenotypic variations that may be seen in CF patients with milder forms of the disease

1.CF is a multisystem disease that stems from a mutation of the CFTR gene, resulting in impaired chloride and water transport across epithelial mucosa throughout the body. 2.Thoracic disease predominates the clinical picture, but multiple other systems are also involved, including sinonasal, pancreas, hepatobiliary, gastrointestinal, genitourinary, and muskuloskeletal systems. 3.CF patients are living longer and radiologists need to recognize these imaging findings in adolescents and adults.